Pamidronic acid Chemical Properties

Melting point:

226-228°C

Boiling point:

658.7±65.0 °C(Predicted)

Density 

1.998±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated)

pka

1.44±0.10(Predicted)

form 

Solid

color 

Light Brown to Beige

Stability:

Hygroscopic

Safety Information

HS Code 

9999999999

MSDS

• Language:English Provider:Delavirdine mesylate

Pamidronic acid Usage And Synthesis

Chemical Properties

White Solid

Originator

Aredia,Novartis,India

Uses

A biphosphonate bone resorption inhibitor.

Uses

anticancer

Definition

ChEBI: Pamidronate is a phosphonoacetic acid.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Rescriptor (Agouron).

Therapeutic Function

Bone resorption suppressant

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