2-Quinazolinamine Chemical Properties

Melting point:

204 °C

Boiling point:

370.7±25.0 °C(Predicted)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

4.86±0.10(Predicted)

color 

Yellow

NIST Chemistry Reference

2-Quinazolinamine(1687-51-0)

Safety Information

HS Code 

2933599590

2-Quinazolinamine Usage And Synthesis

Synthesis

GENERAL STEPS: DMSO (2.0 mL) was added to a 25 mL Schlenk tube protected by nitrogen and equipped with a magnetic stirrer. 2-Bromobenzylamine (1) (0.5 mmol), guanidine hydrochloride (2) (1.0 mmol), CuBr (0.1 mmol, 14.2 mg) and K2CO3 (1.5 mmol, 207 mg) were added sequentially. The reaction mixture was stirred at 80-120 °C for 24 h, followed by continued stirring for 0.5 h in air. After completion of the reaction, the mixture was cooled to room temperature, filtered, and the solid fraction was washed with ethyl acetate (3 x 3 mL). The filtrates were combined and concentrated by rotary evaporator and the residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give the target product 2-aminoquinazoline.

References

[1] Synlett, 2013, vol. 24, # 16, p. 2089 - 2094

2-Quinazolinamine(1687-51-0)Related Product Information

• Quinoxaline
• Cefazolin
• Cefazolin sodium salt
• Quinazoline
• Terazosin hydrochloride
• 2-HYDRAZINOQUINOXALINE
• Sulfaquinoxaline
• LUMICHROME
• Prazosin
• ALLOXAZINE
• 2,4-DIAMINO-6-NITROQUINAZOLINE
• 7-AMINO-4(1H)-QUINAZOLINONE
• 2-CHLORO-6,7-DIMETHOXY-4-AMINOQUINAZOLINE,QUINAZOLINAMINE,4-Quinazolinamine, 2-chloro-6,7-dimethoxy-
• Gefitinib
• 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
• PD153035 HCl
• 6,7-DIMETHOXY-2-PIPERAZINO-4-AMINOQUINAZOLINE
• 2-chloro-3-pyrrolidin-1-yl-quinoxaline