3,4-Dimethylphenylacetic Acid Chemical Properties

Melting point:

93.5-94.5 °C

Boiling point:

297.3±9.0 °C(Predicted)

Density 

1.098±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.40±0.10(Predicted)

form 

Solid

Appearance

White to off-white Solid

Water Solubility 

Slightly soluble in water.

Safety Information

HS Code 

2916399090

3,4-Dimethylphenylacetic Acid Usage And Synthesis

Uses

3,4-Dimethylphenylacetic acid, is is used as an intermediate in organic synthesis. It is also used as a fine chemical intermediate.

Synthesis

In a 1 liter three-necked flask, 300 g of a 30% hydrochloric acid solution was added under nitrogen protection. The reaction system was heated to 80-95°C. 200 g of the intermediate 1-(2,2,2-trichloroethyl)-3,4-dimethylbenzene was slowly added dropwise. After the dropwise addition was completed, the reaction was kept at temperature for 10 hours. After completion of the reaction, the system was quenched by cooling to room temperature. After filtration, washing and drying, 190 g of crude product was obtained. The crude product was recrystallized using 200 g of toluene, resulting in 101.1 g of pure 3,4-dimethylphenylacetic acid with a melting point of 87-89°C and an HPLC purity greater than 99 wt%.

References

[1] Patent: CN107417509, 2017, A. Location in patent: Paragraph 0092

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