2,3,5-Trichloropyridine Chemical Properties

Melting point:

46-50 °C (lit.)

Boiling point:

219 °C (lit.)

Density 

1.539±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.92±0.10(Predicted)

form 

Solid

color 

Off-white to pale yellow

Water Solubility 

Slightly soluble in water.

BRN 

119384

InChI

InChI=1S/C5H2Cl3N/c6-3-1-4(7)5(8)9-2-3/h1-2H

InChIKey

CNLIIAKAAMFCJG-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(Cl)C=C1Cl

CAS DataBase Reference

16063-70-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

52/53-36/37/38

Safety Statements 

61-37/39-26

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

2

RTECS 

UU0525000

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

29333990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Sens. 1

Toxicity

mouse,LD50,intraperitoneal,430mg/kg (430mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LIVER: FATTY LIVER DEGERATIONBEHAVIORAL: ANTIPSYCHOTIC,Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.

MSDS

• Language:English Provider:SigmaAldrich

2,3,5-Trichloropyridine Usage And Synthesis

Chemical Properties

Beige powder

Uses

2,3,5-Trichloropyridine may be used in the synthesis of 3,5-dichloro-2-arylpyridines via palladium acetate-catalyzed ligand-free Suzuki reaction with arylboronic acids.

General Description

Separation and migration behavior of 2,3,5-trichloropyridine has been studied by micellar electrokinetic chromatography. Crystal structure of 2,3,5-trichloropyridine has been reported. Mol-ecules of 2,3,5-trichloropyridine in crystal are stacked along the short a axis and forms a layer structure. 2,3,5-Trichloropyridine is reported to undergo nucleophilic displacement reaction in ionic liquid to afford the corresponding 2-aryloxylpropionate.

Synthesis

Add 60g methanol to 1000mL four-necked flask, put in 100g 2,3,5,6-tetrachloropyridine, 31.7g hydrazine hydrate, warming to 60-65 C, holding reaction about 2 hours, the end of the reaction, lowering the temperature to 0-5 C, stirring for 1 hour, filtration, the solid that is 2,3,5-trichloro 6-hydrazinium hydrate pyridine, drying to get a white solid 101.6g, yield 96%, content 98.5%.

To a 1000 ml four-necked flask was added 100 g of 2,3,5-trichloro 6-hydrazinium hydrate pyridine, 50g content 5% sodium hydroxide aqueous solution, warming to 70 ~ 75 C, dropwise addition of 387.6g content 10% sodium hypochlorite aqueous solution, holding temperature 70 ~ 75 C, the reaction for 1 hour, the end of the reaction, lower the temperature to 5 ~ 10 C, stirring for 1 hour, filtration to obtain 2,3,5-trichloropyridine crude, distillation under reduced pressure to get the product, a light yellow Solid, yield: 95%, content: 98%.

2,3,5-Trichloropyridine(16063-70-0)Related Product Information

• Trichloroethylene
• Sucralose
• Trichlorosilane
• 2-Chloro-5-chloromethylpyridine
• 3-Aminopyridine
• 3,5,6-trichloropyridine-2-o
• 2,5-Dimethylpyridine
• 2,3,5-TRICHLORO-4-PYRIDINOL
• 4-amino-2,3,5-trichloropyridine,4-AMINO-2,3,5-TRICHLOROPYRIDINE, 98
• Chlorpyrifos
• Pentachloropyridine
• 2,3,5,6-Tetrachloropyridine-4-thiol
• PICLORAM METHYL ESTER
• Picloram
• Triclopyr 2-butoxyethyl ester
• Chlorpyrifos-methyl
• 2 4 6-TRICHLOROPYRIDINE 97,2,4,6-Trichloropyridine
• Chloroform