Basic information Safety Supplier Related

Sorbinil

Basic information Safety Supplier Related

Sorbinil Basic information

Product Name:
Sorbinil
Synonyms:
  • Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)-
  • (4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
  • (4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione
  • (S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
  • CP-45634
  • (4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
  • (S)-(+)-Sorbinil
  • (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
CAS:
68367-52-2
MF:
C11H9FN2O3
MW:
236.2
Mol File:
68367-52-2.mol
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Sorbinil Chemical Properties

Melting point:
241-243°
alpha 
D25 +54.0° (c = 1 in methanol)
Density 
1.52
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
8.91±0.20(Predicted)
color 
white to off-white
optical activity
[α]/D +50 to +60°, c = 1 in methanol
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Sorbinil Usage And Synthesis

Uses

Enzyme inhibitor (aldose reductase).

Uses

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.

Definition

ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.

Biochem/physiol Actions

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.

SorbinilSupplier

ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com