Sorbinil
Sorbinil Basic information
- Product Name:
- Sorbinil
- Synonyms:
-
- Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)-
- (4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
- (4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione
- (S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
- CP-45634
- (4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
- (S)-(+)-Sorbinil
- (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
- CAS:
- 68367-52-2
- MF:
- C11H9FN2O3
- MW:
- 236.2
- Mol File:
- 68367-52-2.mol
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Sorbinil Chemical Properties
- Melting point:
- 241-243°
- alpha
- D25 +54.0° (c = 1 in methanol)
- Density
- 1.52
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 8.91±0.20(Predicted)
- color
- white to off-white
- optical activity
- [α]/D +50 to +60°, c = 1 in methanol
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Sorbinil Usage And Synthesis
Uses
Enzyme inhibitor (aldose reductase).
Uses
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Definition
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
SorbinilSupplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai Synchem Pharma Co., ltd
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
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Sorbinil(68367-52-2)Related Product Information
- (S)-1-(3-Fluorophenyl)ethanamine
- 2-ETHOXYPHENETHYLAMINE
- H-PHG-NH2 HCL
- (R)-1-(3-Fluorophenyl)ethylamine
- 6-FLUOROCHROMAN
- 3-(4-fluorophenoxy)propan-1-amine
- N-(2-METHOXYPHENETHYL)UREA
- 6-FLUORO-4-CHROMANONE HYDANTOIN
- 1-(3-FLUOROPHENYL)PROPYLAMINE
- Sorbinil
- FIDARESTAT
- (S)-(+)-NIRVANOL
- [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE
- (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE
- 2-(2-METHOXYPHENYL)-ACETAMIDE
- 3-(3-FLUOROPHENYL)-DL-BETA-ALANINOL
- 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI)
- 6-FLUORO-CHROMAN-4-YLAMINE HYDROCHLORIDE