6-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine Chemical Properties

Melting point:

154-156°C

Boiling point:

418.9±28.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

-0.78±0.20(Predicted)

color 

Off-White

InChI

InChI=1S/C14H10N2O2/c17-13-11-7-4-8-15-12(11)14(18)16(13)9-10-5-2-1-3-6-10/h1-8H,9H2

InChIKey

DWUBVULEMQOCPO-UHFFFAOYSA-N

SMILES

C12C(=O)N(CC3=CC=CC=C3)C(=O)C1=CC=CN=2

6-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine Usage And Synthesis

Chemical Properties

Off-White Solid

Synthesis

6-Benzyl-6H-pyrrolo[3,4-B]pyridine-5,7-dione was synthesized using 2,3-pyridinedicarboxylic acid and benzylamine as raw materials by the same method as described previously, and the reaction conditions were adjusted to react at 150 °C for 18-26 hours. After completion of the reaction, the crude product was purified using a 15 cm x 2.5 cm silica gel column with a hexane solution of 60-80% ethyl acetate as eluent. The yield of the purified product was recorded in Table 3. Special note: Saturated NH4Cl solution was used instead of 1 M HCl in the step of washing pyridine derivatives.

References

[1] Tetrahedron, 2015, vol. 71, # 48, p. 9101 - 9111
[2] Patent: CN105777750, 2016, A. Location in patent: Paragraph 0024; 0025; 0040
[3] Asian Journal of Chemistry, 2013, vol. 25, # 15, p. 8701 - 8707

6-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine(18184-75-3)Related Product Information

• N-Methyl Moxifloxacin
• Moxifloxacin Related Impurity 2
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• (4aS,7aS)-1-methyloctahydro-1H-pyrrolo[3,4-b]pyridine
• 6-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine
• 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione
• 6-BENZYL-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDINE