4-Methoxyphenethylamine Chemical Properties

Melting point:

249-251°C

Boiling point:

138-140 °C20 mm Hg(lit.)

Density 

1.031 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.538(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

9.96±0.10(Predicted)

form 

liquid

color 

light yellow

BRN 

508967

CAS DataBase Reference

55-81-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneethanamine, 4-methoxy-(55-81-2)

EPA Substance Registry System

Benzeneethanamine, 4-methoxy- (55-81-2)

Safety Information

Hazard Codes 

C,T

Risk Statements 

34

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 2735 8/PG 3

WGK Germany 

3

RTECS 

SH7875000

F 

10-23

Hazard Note 

Toxic/Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29222900

MSDS

• Language:English Provider:4-Methoxy-2-phenylethylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Methoxyphenethylamine Usage And Synthesis

Chemical Properties

clear colorless to slightly yellow liquid

Uses

4-Methoxyphenethylamine an inhibitor of the deamination of tyramine and tryptamine. It is intermediates of ritodrine. ritodrine is an adrenergic β2 receptor agonists used to prevent premature birth.

Application

4-Methoxyphenethylamine was used in the synthesis of :
pyrrolo[3,2-c]carbazole
poly(4-methoxyphenethylamine), required for the immobilization of nitrogenated bases and oligonucleotides
organopolyphosphazenes such as poly[bis(4-methoxy benzylamino)polyphosphazene] and poly[bis(4-methoxyphenethylamino)polyphosphazene]
4-methoxyphenethylamine was reacted with CDI and obtained N-substituted imidazolide intermediate.

Definition

ChEBI: 4-methoxyphenylethylamine is a primary amino compound consisting of ethylamine having a 4-methoxyphenyl substituent at the 2-position. It derives from a hydride of a 2-phenylethylamine.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 15, p. 214, 1972 DOI: 10.1021/jm00272a029

General Description

4-Methoxyphenethylamine inhibits the monoamine oxidase-catalyzed deamination of both tyramine and tryptamine.

4-Methoxyphenethylamine (55-81-2)Related Product Information

• 4-Methoxyphenol
• p-Anisaldehyde
• L-1-Phenylethylamine
• 4-Methoxybenzylchloride
• 4'-Methoxyacetophenone
• 2-Phenylethylamine hydrochloride
• 4-Methoxybenzyl cyanide
• 4-Methoxyphenylacetic acid
• 4-Methoxyphenylacetone
• 4-Methoxyphenylhydrazine hydrochloride
• Anisole
• (Trifluoromethoxy)benzene
• 2-METHOXYETHYLAMINE
• p-Anisidine
• Ethylamine
• Tyramine
• 3-Methoxyphenethylamine
• 4-Methoxystyrene