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Atractylodin

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Atractylodin Basic information

Product Name:
Atractylodin
Synonyms:
  • ATRACTYLODIN
  • (e,e)-2-(1,7-nonadiene-3,5-diynyl)furan
  • Atractydin
  • Atisine chloride Atractydin
  • Furan,2-(1E,7E)-1,7-nonadiene-3,5-diyn-1-yl-
  • (1E,7E)-1-(2-Furyl)-1,7-nonadiene-3,5-diyne
  • 2-[(1E,7E)-1,7-Nonadiene-3,5-diynyl]furan
  • Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)-
CAS:
55290-63-6
MF:
C13H10O
MW:
182.22
Product Categories:
  • Miscellaneous Natural Products
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
55290-63-6.mol
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Atractylodin Chemical Properties

Melting point:
52 °C
Boiling point:
305.5±34.0 °C(Predicted)
Density 
1.056±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
form 
powder
color 
Brown
InChI
InChI=1S/C13H10O/c1-2-3-4-5-6-7-8-10-13-11-9-12-14-13/h2-3,8-12H,1H3/b3-2+,10-8+
InChIKey
GRBKWAXRYIITKG-QFMFQGICSA-N
SMILES
C(/C1OC=CC=1)=C\C#CC#C/C=C/C
LogP
4.583 (est)
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Atractylodin Usage And Synthesis

Chemical Properties

Atractylodes is colorless needle crystal, melting point 50.5 ~ 53 ℃.

Uses

Atractylodin has hepatoprotective effects, hypoglycemic effects, anti-inflammatory and anti-tumor effects, antibacterial and antiviral effects, and can be used for content determination/identification/pharmacological experiments.

Definition

ChEBI: Atractylodin is a member of furans.

Pharmacology

Atractylodes is a substance extracted from the dried rhizomes of Atractylodes japonica or Atractylodes japonica. Volatile oil is the main active ingredient in Atractylodes Rhizoma, among which the highest content is Atractylodes Rhizoma, which has pharmacological activities such as lowering blood sugar, diuresis, promoting gastric emptying, anti-inflammatory and anti-tumor.

in vivo

Atractylodin (40 mg/kg intraperitoneally injected for 14 days) can improve the survival rate of mice in a mouse model of colitis induced by sodium dextran sulfate[2].
Atractylodin (20, 40, 80 mg/kg, gavage) alleviates the oxidative stress of HepG2 cells induced by high-fat diet (HFD) and palmitic acid (PA) in mice[3].

Animal Model:DSS-Induced Colitis Mouse Model[2]
Dosage:40 mg/kg
Administration:i.p.
Result:Reduced colitis symptoms and increased survival rate.
Animal Model:NAFLD mice model[3]
Dosage:20, 40, 80 mg/kg
Administration:i.g.
Result:Reduced the release of ALT, AST, ROS and MDA.
Increased the TG, GSH and SOD.

AtractylodinSupplier

Chengdu Herbpurify Co.Ltd. Gold
Tel
2355253622; 18981954830
Email
2355253622@qq.com;
Wuhan Lvjing Fenghua Biotechnology Co., Ltd. Gold
Tel
19972070065
Email
201746457@qq.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
China Langchem Inc.
Tel
0086-21-58956006
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