5-Chloro-2-nitropyridine Chemical Properties

Melting point:

119-123℃

Boiling point:

275.3±20.0 °C(Predicted)

Density 

1.489±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

crystalline powder

pka

-4.87±0.22(Predicted)

color 

White to very faint yellow

InChI

InChI=1S/C5H3ClN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H

InChIKey

YUBHMOQVHOODEI-UHFFFAOYSA-N

SMILES

C1([N+]([O-])=O)=NC=C(Cl)C=C1

CAS DataBase Reference

52092-47-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,Xn

Risk Statements 

20/21/22-36/37/38-50-41-22

Safety Statements 

26-36/37/39-36-61-37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

2933399990

5-Chloro-2-nitropyridine Usage And Synthesis

Uses

5-Chloro-2-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

To concentrated H2SO4 (50 ml) was added 30 % H2O2 (25mL) at 0 ??C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2SO4 (20 mL) was added at 0 ??C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorously stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine. 5-chloro-2-nitropyridine. MS m/z 159 (M+ 1)+.

References

[1] Patent: US6849647, 2005, B1. Location in patent: Page/Page column 145
[2] Yakugaku Zasshi, 1952, vol. 72, p. 381
[3] Chem.Abstr., 1953, p. 6403
[4] Zhurnal Obshchei Khimii, 1940, vol. 10, p. 1105
[5] Chem. Zentralbl., 1940, vol. 111, # II, p. 3474

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