4'-Methylpropiophenone Chemical Properties

Melting point:

7.2 °C

Boiling point:

238-239 °C(lit.)

Density 

0.993 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.528(lit.)

Flash point:

229 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in chloroform and hexane.

form 

Oil

color 

Colourless

Specific Gravity

0.99

BRN 

2042137

InChI

InChI=1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3

InChIKey

PATYHUUYADUHQS-UHFFFAOYSA-N

SMILES

C(C1=CC=C(C)C=C1)(=O)CC

CAS DataBase Reference

5337-93-9(CAS DataBase Reference)

NIST Chemistry Reference

4'-Methylpropiophenone(5337-93-9)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29143990

MSDS

• Language:English Provider:4'-Methylpropiophenone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4'-Methylpropiophenone Usage And Synthesis

Chemical Properties

clear light yellow liquid

Uses

4'-methylpropiophenone has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants. The substance is also a starting material in the synthesis of 4-methylmethcathinone (mephedrone). Mephedrone has been encountered as a ‘legal high’ and on the illicit drug market masquerading as cocaine (in powder form), MDMA (in tablet form) and as an adulterant. According to the 2016 European Drugs Market Report produced by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), mephedrone has created a specific demand and carved its own distinct market share.

Uses

4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

Application

4′-Methylpropiophenone can be used as a building block to synthesize:
N-(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.
Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.
Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.

Definition

ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

Synthesis

4'-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.

4'-Methylpropiophenone(5337-93-9)Related Product Information

• Kresoxim-methyl
• Bensulfuron methyl
• Methylparaben
• Methyl acrylate
• 3'-Hydroxypropiophenone
• p-Toluenesulfonic acid
• Isobutyrophenone
• p-Toluic acid
• METHYL THIOPHENE-2-CARBOXYLATE
• Thiophanate-methyl
• p-Tolualdehyde
• Methyl
• Tolperisone Impurity B
• M-METHYLPROPIOPHENONE
• Tolperisone Impurity C
• ETHYL-O-TOLYL KETONE
• 4'-Methylacetophenone
• Tolperisone hydrochloride