N-LAUROYL-D-ERYTHRO-SPHINGOSINE Chemical Properties

Melting point:

70 - 72°C

Boiling point:

579.38°C (rough estimate)

Density 

0.9777 (rough estimate)

refractive index 

1.6310 (estimate)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)

pka

13.54±0.20(Predicted)

form 

Solid

color 

White to Off-White

BRN 

1717021

Safety Information

Safety Statements 

24/25

WGK Germany 

3

MSDS

• Language:English Provider:ACROS

N-LAUROYL-D-ERYTHRO-SPHINGOSINE Usage And Synthesis

Chemical Properties

white powder

Uses

C12 Ceramide (d18:1/12:0) or N-lauroyl-D-erythro-sphingosine has been used:

• as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions
• as an internal standard for lipid extraction in U87MG (human glioma cell line)
• as an internal standard for the quantification of ceramide using liquid chromatography-mass spectrometry (LC-MS) in rat tissues

Uses

Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness.

Definition

ChEBI: N-dodecanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as dodecanoyl (lauroyl). It is functionally related to a dodecanoic acid.

General Description

Ceramide is a sphingolipid with long acyl chain attached to a fatty. It is synthesized in the endoplasmic reticulum by ceramide synthase.

Biochem/physiol Actions

Ceramides?are signaling sphingolipids, which are implicated in regulating stress responses and inflammation. It also regulates cell growth arrest, differentiation and apoptosis.

N-LAUROYL-D-ERYTHRO-SPHINGOSINE(74713-60-3)Related Product Information

• C18-CEREBROSIDE
• C12 NBD-SPHINGOMYELIN
• N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-CERAMIDE
• N-OCTADECANOYLSPHING-OSYLPHOSPHORYLCHOLINE
• N-LAUROYL-D-ERYTHRO-SPHINGOSINE
• C14 CERAMIDE
• C20 CERAMIDE
• D-ERYTHRO-SPHINGOSINE
• CERAMIDE TRIHEXOSIDES, [GALACTOSE-6-3H]
• C18-D-ERYTHRO-SPHINGOSINE
• (2S,3R,4E)-N-TETRACOSANOYL SPHINGOSINE
• N-OCTANOYL-D-ERYTHRO-DIHYDROSPHINGOSINE [4,5-3H] 1-PHOSPHATE
• C24:1 CERAMIDE
• GALACTOSYL CERAMIDE, [GALACTOSE-6-3H]
• C16-D-ERYTHRO-SPHINGOSINE
• N-PALMITOYL-D-ERYTHRO-SPHINGOSINE, [PALMITOYL-1-14C]
• BETA-D-GALACTOPYRANOSYL(1-4)-BETA-D-GLUCOPYRANOSYL CERAMIDE
• C12 NBD LACTOSYL CERAMIDE