1-BENZHYDRYLPIPERAZINE Chemical Properties

Melting point:

90-93 °C

Boiling point:

185°C/2mmHg(lit.)

Density 

1.0546 (rough estimate)

vapor pressure 

0.001Pa at 20℃

refractive index 

1.5794 (estimate)

Flash point:

115 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Methanol (Slightly)

pka

9.05±0.10(Predicted)

form 

Crystalline Powder

color 

White to light yellow

Water Solubility 

0.45 g/L (20 ºC)

Sensitive 

Air Sensitive

BRN 

222773

LogP

0.6 at 20℃

CAS DataBase Reference

841-77-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzhydryl piperazine(841-77-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

TL6465000

F 

34

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:Benzhydrylpiperazine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-BENZHYDRYLPIPERAZINE Usage And Synthesis

Chemical Properties

white to light yellow crystalline powder

Uses

Cinnarizine (C465300) impurity.

Uses

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.

Uses

1-Benzhydrylpiperazine is an intermediate used in drug synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

General Description

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.

Flammability and Explosibility

Not classified

1-BENZHYDRYLPIPERAZINE(841-77-0)Related Product Information

• 1-(DiphenylMethyl)-4-[(1RS,3E)-4-phenyl-1-[(E)-2-phenylethenyl)-3-buten-1-yl]piperazine
• IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine
• IMp. C (EP): (4-(DiphenylMethyl)-1,1-bis[(E)-3-phenylprop-2-enyl]piperaziniuM Chloride
• (Z)-Cinnarizine
• Chlorodiphenylphosphine
• CHLORCYCLIZINE
• Cyclizine
• 1-BENZHYDRYLPIPERAZINE
• Hydroxyzine dihydrochloride
• CHLORCYCLIZINE HYDROCHLORIDE
• Flunarizine dihydrochloride
• Meclizine dihydrochloride
• 4,4'-Difluorobenzhydrylpiperazine
• 1-(4-Chlorobenzhydryl)piperazine
• Stugeron
• 1-(4,4'-DICHLOROBENZHYDRYL)PIPERAZINE
• Buterizine
• Piperazine