BOC-ALA-GLY-OH Chemical Properties

Melting point:

104-105 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))

Boiling point:

484.4±30.0 °C(Predicted)

Density 

1.190±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

3.42±0.10(Predicted)

form 

Solid

color 

White to off-white

optical activity

Consistent with structure

BOC-ALA-GLY-OH Usage And Synthesis

Uses

(S)-2-(2-((tert-Butoxycarbonyl)amino)propanamido)acetic acid is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

General procedure for the synthesis of (S)-2-(2-((tert-butoxycarbonyl)amino)propanoylamino)acetic acid from the compound (CAS: 26061-06-3): compound 9a (2.6 g, 10 mmol) was dissolved in 50 mL of methanol, 1 M NaOH solution (30 mL) was added, and the reaction was stirred for 3 h at room temperature. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was adjusted to pH 2-3 with 1 M hydrochloric acid.Subsequently, the mixture was extracted three times with ethyl acetate (EtOAc). The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). After filtration, ethyl acetate was removed by evaporation under reduced pressure to give the target product compound 10a as a white solid in 92.4% yield with a melting point of 102-105°C.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

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