Ethyl2,6-PyridinedicarboxylateMono Chemical Properties

Melting point:

116-117℃

Boiling point:

396.2±27.0 °C(Predicted)

Density 

1.304±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.27±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

Ethyl2,6-PyridinedicarboxylateMono Usage And Synthesis

Synthesis

The general synthetic procedure was as follows. 2,6-Pyridinedicarboxylic acid (1, 1.5 g, 8.98 mmol) was mixed with 24 mL of dichlorosulfoxide (SOCl2). The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, excess dichlorosulfoxide was removed by distillation under reduced pressure. To the resulting white solid, 50 mL of tetrahydrofuran (THF) was added. After the solid was completely dissolved, ethanol (10.5 mmol) and N,N-diisopropylethylamine (DIEA, 10.5 mmol) were added slowly via syringe. The reaction mixture was heated to reflux for 4 hours. At the end of the reaction, the solvent was removed by distillation under reduced pressure. The residue was separated and purified by column chromatography to afford the target products diethyl 2,6-pyridinedicarboxylate and monoethyl 2,6-pyridinedicarboxylate.

References

[1] Tetrahedron, 2011, vol. 67, # 44, p. 8458 - 8464

Ethyl2,6-PyridinedicarboxylateMono(21855-16-3)Related Product Information

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• SALOR-INT L160334-1EA
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• Diethyl 4-methylpyridine-2,6-dicarboxylate
• Dibutyl 4-butoxy-2,6-pyridinedicarboxylate
• DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE