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Hydrocortisone

Basic information Safety Supplier Related

Hydrocortisone Basic information

Product Name:
Hydrocortisone
Synonyms:
  • hydrocortisone aceponate
  • [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
  • [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
  • propionic acid [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester
  • Hydrocortisone 17-Propionate 21-Acetate
  • Hydrocortisonepropylacetate
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11β)-
  • Efficort
CAS:
74050-20-7
MF:
C26H36O7
MW:
460.56
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • API
Mol File:
74050-20-7.mol
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Hydrocortisone Chemical Properties

Melting point:
144-146°C
Density 
1.23±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Pale Beige
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Hydrocortisone Usage And Synthesis

Description

Hydrocortisone aceponate is the 17-a-propionate derivative of hydrocortisone-21-acetate. Its is reportedly significantly superior to the latter in the treatment of dermatoses of varying severity.

Chemical Properties

White to Off-White Solid

Originator

Beiersdorf (W.Germany)

Uses

A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid.

Definition

ChEBI: Hydrocortisone aceponate is a corticosteroid hormone.

brand name

Retef

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