Basic information Safety Supplier Related

Licostinel

Basic information Safety Supplier Related

Licostinel Basic information

Product Name:
Licostinel
Synonyms:
  • Licostinel
  • 2,3-Quinoxalinedione, 6,7-dichloro-1,4-dihydro-5-nitro-
  • 6,7-dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione
  • 6,7-dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione(WXC05743)
  • CGP 63446
  • CGP-63446
  • Licostinel, 10 mM in DMSO
CAS:
153504-81-5
MF:
C8H3Cl2N3O4
MW:
276.03
Mol File:
153504-81-5.mol
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Licostinel Chemical Properties

Melting point:
342-344°
form 
Yellow powder.
color 
Light yellow to light brown
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Licostinel Usage And Synthesis

Uses

NMDA antagonist.

Uses

5-Nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione is a strong and selective NMDA receptor glycine site antagonist. CNS therapeutic agents.

in vivo

Animal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice.
The transient model of focal ischemia in Wistar and Sprague –Dawley rats [2
Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h
Administration:A single intravenous injection bolus continuous infusion
Result:Decreased infarct size.
Animal Model:Male Sprague-Dawley rats [3]
Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins
Administration:Intravenous injection (i.v.) bolus continuous infusion
Result:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.

LicostinelSupplier

Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
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Licostinel(153504-81-5)Related Product Information