Basic information Safety Supplier Related

Nemadectin

Basic information Safety Supplier Related

Nemadectin Basic information

Product Name:
Nemadectin
Synonyms:
  • Nemadectin
  • (6R,23S,25S)-5-O-Demethyl-28-deoxy-25-[(E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-hydroxymilbemycin B
  • AC-088
  • LL-F-28249α
  • S541A, LL-F28249 alpha
  • LL-F28249 alpha
  • Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-
  • (2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
CAS:
102130-84-7
MF:
C36H52O8
MW:
612.79
Mol File:
102130-84-7.mol
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Nemadectin Chemical Properties

alpha 
D26 +133° (c = 0.3 in acetone)
Boiling point:
789.4±60.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
pka
12.46±0.70(Predicted)
form 
Solid
color 
White to off-white
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Safety Information

RIDADR 
2588
HazardClass 
6.1(b)
PackingGroup 
III
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Nemadectin Usage And Synthesis

Description

The nemadectins are fermentation products of Streptomyces cyaneogriseus noncyanogenus. Structurally, the nemadectins lack a disaccharide group at C-13 but differ from the milbemycins proper because they contain a trisubstituted double bond at C-26 in their side chains.

Uses

Nemadectin is a potent antiparasitic macrolide lactone.

Uses

Nemadectin is the dominant member of a class of milbemycins bearing unsaturated longer chain groups at the 25-position. Nemadectin shows pronounced nematocidal and insecticidal activity. Nemadectin is the starting material for moxidectin, a commercial anthelmintic.

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