Nemadectin
Nemadectin Basic information
- Product Name:
- Nemadectin
- Synonyms:
-
- Nemadectin
- (6R,23S,25S)-5-O-Demethyl-28-deoxy-25-[(E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-hydroxymilbemycin B
- AC-088
- LL-F-28249α
- S541A, LL-F28249 alpha
- LL-F28249 alpha
- Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-
- (2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
- CAS:
- 102130-84-7
- MF:
- C36H52O8
- MW:
- 612.79
- Mol File:
- 102130-84-7.mol
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Nemadectin Chemical Properties
- alpha
- D26 +133° (c = 0.3 in acetone)
- Boiling point:
- 789.4±60.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- pka
- 12.46±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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Nemadectin Usage And Synthesis
Description
The nemadectins are fermentation products of Streptomyces cyaneogriseus noncyanogenus. Structurally, the nemadectins lack a disaccharide group at C-13 but differ from the milbemycins proper because they contain a trisubstituted double bond at C-26 in their side chains.
Uses
Nemadectin is a potent antiparasitic macrolide lactone.
Uses
Nemadectin is the dominant member of a class of milbemycins bearing unsaturated longer chain groups at the 25-position. Nemadectin shows pronounced nematocidal and insecticidal activity. Nemadectin is the starting material for moxidectin, a commercial anthelmintic.
NemadectinSupplier
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