Quinagolide Chemical Properties

Melting point:

122.5-124°

Boiling point:

539.1±60.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

pka

10.31±0.40(Predicted)

Quinagolide Usage And Synthesis

Uses

Quinagolide (CV205-502) is a non-ergot dopamine D(2) receptor agonist that promotes dopamine activity. Quinagolide has shown effectiveness in modulating endocrine function, particularly in inhibiting disorders associated with dopamine deficiency. Quinagolide is used to suppress hyperprolactinemia and corresponding clinical symptoms, showing good efficacy. Quinagolide's biological activity enables its use as an important research compound in drug isolation and analysis[1].

Definition

ChEBI: Quinagolide is an organonitrogen heterocyclic compound and an organic heterotricyclic compound.

Clinical Use

Hyperprolactinaemia

Metabolism

Quinagolide is extensively metabolised. Quinagolide and its N-desethyl analogue are the biologically active but minor components. Their inactive sulphate or glucuronide conjugates represent the major circulating metabolites. Studies performed with 3 H-labelled quinagolide revealed that more than 95% of the drug is excreted as metabolites. About equal amounts of total radioactivity are found in faeces and urine.

References

[1] Chiral Separations by Host-Guest Complexation with Cyclodextrin and Crown Ether in Capillary Zone Electrophoresis

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