Tixocortol
Tixocortol Basic information
- Product Name:
- Tixocortol
- Synonyms:
-
- (11β)-11,17-Dihydroxy-21-Mercaptopregn-4-ene-3,20-dione
- 11β,17-Dihydroxy-21-Mercaptoprogesterone
- Cortisol 21-Thiol
- Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-mercapto-, (11β)-
- CAS:
- 61951-99-3
- MF:
- C21H30O4S
- MW:
- 378.53
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Sulfur & Selenium Compounds
- Mol File:
- 61951-99-3.mol
Tixocortol Usage And Synthesis
Originator
Pivalone,Jouveinal,France,1978
Uses
Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling.
Definition
ChEBI: A steroid sulfide in which the sulfanyl group is at C-21 of a polyoxygenated derivative of pregn-4-ene.
Manufacturing Process
In a reactor of 50 liters, sodium S-thiopivalate is prepared from 100 g of S_x0002_thiopivalic acid (0.844 mol), 214 cc of solution of sodium methylate, 3.95 M
(0.844 mol) in 25 liters of anhydrous acetone.
There are then added 285 g (0.603 mol) of dihydroxy-11β,17α-iodo-21-dioxo-
3,20-pregnene-4 and the mixture is brought up to the acetone reflux for two
hours. The solvent is eliminated by distillation under vacuum until there is
obtained a syrupy residue which is poured into 10 liters of iced water. The
insoluble part is filtered and dried under vacuum.
The crude product is purified by recrystallization from ethanol; weight: 250 g;
yield: 89.5%.
Therapeutic Function
Antiinflammatory
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