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5-Bromo-2-hydroxyacetophenone

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5-Bromo-2-hydroxyacetophenone Basic information

Product Name:
5-Bromo-2-hydroxyacetophenone
Synonyms:
  • 1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE
  • 2-ACETYL-4-BROMOPHENOL
  • 5'-BROMO-2'-HYDROXYACETOPHENONE
  • 5-BROMO-2-HYDROXYACETOPHENONE
  • 1-(5-bromo-2-hydroxyphenyl)-ethanon
  • AKOS BBS-00006622
  • 2’-hydroxy-5’-bromoacetophenone
  • 5’-bromo-2’-hydroxy-acetophenon
CAS:
1450-75-5
MF:
C8H7BrO2
MW:
215.04
EINECS:
604-457-2
Product Categories:
  • Building Blocks
  • C7 to C8
  • C7 to C8
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatic Acetophenones & Derivatives (substituted)
  • Adehydes, Acetals & Ketones
  • Bromine Compounds
  • Phenols
  • Carbonyl Compounds
  • Ketones
Mol File:
1450-75-5.mol
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5-Bromo-2-hydroxyacetophenone Chemical Properties

Melting point:
58-61 °C(lit.)
Boiling point:
135-143 °C(Press: 16 Torr)
Density 
1.586±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform
pka
9.59±0.18(Predicted)
form 
Solid
color 
White to pale yellow
LogP
3.110 (est)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
KM5556350
HazardClass 
IRRITANT
HS Code 
29147000
Toxicity
mouse,LD50,intraperitoneal,> 1gm/kg (1000mg/kg),Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. Vol. 20, Pg. 480, 1981.

MSDS

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5-Bromo-2-hydroxyacetophenone Usage And Synthesis

Chemical Properties

White to pale yellow crystalline powder

Uses

5?-Bromo-2?-hydroxyacetophenone (5-Bromo-2-hydroxyacetophenone) may be used in ligand in the preparation of tetrahedral metallocene complexes containing vanadium(IV), synthesis of {2?-[1-(5-bromo-2-oxidophenyl) ethylidene] benzohydrazidato (2-)} tris(pyridine) nickel(II)] pyridine solvate, synthesis of N?-[1-(5-bromo-2-hydroxyphenyl)ethylidene]-3,4,5-trihydroxybenzohydrazide dimethyl sulfoxide solvate trihydrate, preparation of 6-bromochromen-4-one.

Preparation

Preparation by Fries rearrangement of 4-bromophenyl acetate with aluminium chloride without solvent between 110° and 160° (84–91%).

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