Ethyl 2-aminopropanoate hydrochloride Chemical Properties

Melting point:

85-87 °C(lit.)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Methanol (Sparingly), Water

form 

Granular Powder and Granules

color 

White

Sensitive 

Hygroscopic

BRN 

3654425

InChI

InChI=1S/C5H11NO2.ClH/c1-3-8-5(7)4(2)6;/h4H,3,6H2,1-2H3;1H

InChIKey

JCXLZWMDXJFOOI-UHFFFAOYSA-N

SMILES

C(=O)(C(N)C)OCC.Cl

CAS DataBase Reference

617-27-6(CAS DataBase Reference)

EPA Substance Registry System

Alanine, ethyl ester, hydrochloride (617-27-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29224999

MSDS

• Language:English Provider:Ethyl 2-aminopropanoate hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl 2-aminopropanoate hydrochloride Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Alanine derivative

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

The general procedure for the synthesis of ethyl 2-aminopropionate hydrochloride from ethanol and DL-alanine was as follows: commercially available DL-alanine (5.00 g, 56.12 mmol) was dissolved in 150 mL of anhydrous ethanol, 5 mL of 37% concentrated hydrochloric acid was added, and the mixture was refluxed for 5 hours. After completion of the reaction, the solvent was removed by evaporation and the resulting colorless oily residue was vacuum dried to give the target product in 92% yield. The product was characterized by 1H NMR (CDCl3): δ 1.05 (t, 3H, J=7.07Hz, -OCH2CH3), 1.45 (d, 3H, J=7.25Hz, -CHCH3), 3.48 (q, 2H, J=7.07Hz, -OCH2CH3), and 4.02 ppm (q, 1H, J=7.25Hz, - CHCH3). High-resolution mass spectrometry (HRMS, ESI, 140 eV) analysis showed that the m/z [M+H+] calculated value for C5H12NO2 was 118.0868 and the measured value was 118.0794.

References

[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994, # 7, p. 1455 - 1462
[2] Dalton Transactions, 2008, # 13, p. 1689 - 1697
[3] Polyhedron, 2014, vol. 67, p. 520 - 528
[4] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350
[5] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2336 - 2350

Ethyl 2-aminopropanoate hydrochloride(617-27-6)Related Product Information

• Phenprobamate
• L-Alanine
• Topotecan hydrochloride
• Ethyl acetate
• D-Alanine
• Trinexapac-ethyl
• DL-Alanine
• Ethyl 3-aminopropanoate hydrochloride
• Ethanol
• Ethyl acrylate
• EC 2.6.1.2
• Ethylparaben
• Glycine ethyl ester hydrochloride
• Ethyl cyanoacetate
• Methyl acrylate
• ISOXADIFEN-ETHYL
• Tris(trimethylsilyl)phosphate
• Methyl DL-2-aminopropanoate hydrochloride