BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Basic information
- Product Name:
- BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
- Synonyms:
-
- 4-methylpiperazino-thiuramdisulfide
- disulfide,bis((4-methyl-1-piperazinyl)thiocarbonyl)
- BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
- EWP 815
- 4-METHYLPIPERAZINO-THIURAMDISULPHIDE
- Bis(4-methyl-1-piperazinylthiocarbonyl) disulfide,98%
- 4-Methylpiperazine-1-carbothioic dithioperoxyanhydride
- Piperazine, 1,1'-(dithiodicarbonothioyl)bis[4-methyl-
- CAS:
- 20231-01-0
- MF:
- C12H22N4S4
- MW:
- 350.59
- EINECS:
- 247-450-6
- Mol File:
- 20231-01-0.mol
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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Chemical Properties
- Melting point:
- 142-143 °C
- Boiling point:
- 450.5±55.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- pka
- 6.63±0.42(Predicted)
- form
- Solid
- color
- White to off-white
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Safety Information
- Safety Statements
- 24/25
- HS Code
- 29335995
- Toxicity
- LD50 oral in rat: > 5gm/kg
MSDS
- Language:English Provider:ACROS
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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Usage And Synthesis
Chemical Properties
yellow crystalline powder
Uses
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2].
in vivo
EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice[2].
| Animal Model: | Female mice (20 g)[2] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 30 min before killed |
| Result: | Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3H-α-methyldopamine. Reduced the amount of 3H-α-Me-NA by 12%. |
References
[1] Fowler CJ, et al. Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):853-9. DOI:10.1042/bj2890853
[2] Carlsson A, et al. On the beta-hydroxylation of (+-)-alpha-methyldopamine in vivo. Eur J Pharmacol. 1968 Dec;5(1):85-92. DOI:10.1016/0014-2999(68)90160-x
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDESupplier
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