4-Nitrobenzaldehyde Chemical Properties

Melting point:

103-106 °C(lit.)

Boiling point:

273.1°C (rough estimate)

Density 

1,496 g/cm³

refractive index 

1.5800 (estimate)

storage temp. 

Store below +30°C.

solubility 

2.34g/l

form 

Crystalline Powder

color 

Yellow to brown

Odor

Odorless

Water Solubility 

Soluble in water, ethanol, benzene, glacial acetic acid. Slightly soluble in ether.

Sensitive 

Air Sensitive

Merck 

14,6587

BRN 

386796

CAS DataBase Reference

555-16-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 4-nitro-(555-16-8)

EPA Substance Registry System

Benzaldehyde, 4-nitro- (555-16-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-43-52/53-36/37/38-68

Safety Statements 

26-36/37-61-24/25-36/37/39-36

WGK Germany 

2

RTECS 

CU7350000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29130000

Toxicity

LD50 orally in Rabbit: 4700 mg/kg LD50 dermal Rat 16000 mg/kg

MSDS

• Language:English Provider:4-Nitrobenzaldehyde
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Nitrobenzaldehyde Usage And Synthesis

Chemical Properties

YELLOW TO BROWN CRYSTALLINE POWDER

Uses

4-Nitrobenzaldehyde is a benzaldehyde with a nitro group in the para position. It is used as a reagent in decarboxylative aldol reactions that are catalyzed by lipases and proteases in organic co-solvent mixtures.

Uses

4-Nitrobenzaldehyde was used in the preparation of homoallylic alcohols. It was also used to develop and evaluate a series of tripeptide organocatalysts.

Definition

ChEBI: 4-nitrobenzaldehyde is a C-nitro compound that is benzaldehyde substituted at the para-position with a nitro group. It is a C-nitro compound and a member of benzaldehydes.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 252, 1956 DOI: 10.1021/ja01582a072
Tetrahedron Letters, 28, p. 4285, 1987 DOI: 10.1016/S0040-4039(00)96486-4

Purification Methods

Purify it as for m-nitrobenzaldehyde above. [Beilstein 7 IV 589.]

4-Nitrobenzaldehyde(555-16-8)Related Product Information

• Sodium 3-nitrobenzenesulphonate
• 4-Hydroxy-3-nitrobenzaldehyde
• 4-Nitrophenylacetic acid
• 3-NITRO BENZALDEHYDE
• p-Nitrophenylacetonitrile
• 4-Nitrobenzonitrile
• o-Nitrobenzaldehyde(2-Nitrobenzaldehyde),NITROBENZALDEHYDE-2,O-NITROBENZALDEHYDE
• 4-Nitrobenzoic acid
• 4-Nitrobenzeneethanol
• 4-NITROCINNAMALDEHYDE
• 4-Bromobenzaldehyde
• 4-Hydroxybenzoic acid
• 3-(4-Hydroxyphenyl)propionic acid
• 4-Nitrobenzyl alcohol
• 4-Bromomethylbenzoic acid
• 4'-Hydroxyacetophenone
• 4-Formylbenzoic acid
• 4-Hydroxycinnamic acid