Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antineoplastic agents >  Other antineoplastic Drugs >  Panitumumab

Panitumumab

Basic information Safety Supplier Related

Panitumumab Basic information

Product Name:
Panitumumab
Synonyms:
  • Panitumumab
  • Abx-egf
  • Abx-egf mab
  • Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer
  • Unii-6A901E312a
  • Vectibix
  • Abenix
  • Panitumumab USP/EP/BP
CAS:
339177-26-3
MW:
0
Mol File:
Mol File
More
Less

Panitumumab Chemical Properties

storage temp. 
Store at -20°C
More
Less

Panitumumab Usage And Synthesis

Description

Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody that is highly selective for the epidermal growth factor receptor (EGFR), and it is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression of EGFR is detected in many human cancers, including those of the colon and rectum. Panitumumab blocks the binding of ligands such as epidermal growth factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing cell lines, which results in inhibition of EGF-dependent tumor cell activation, induction of apoptosis, and decreased pro-inflammatory cytokine and vascular growth factor production. In vitro, panitumumab binds EGFR with high affinity (KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431. .

Originator

Abgenix (US)

Uses

Antineoplastic.

brand name

Vectibix

Clinical Use

Monoclonal antibody:
Treatment of metastatic colorectal cancer

Drug interactions

Potentially hazardous interactions with other drugs
Cytotoxics: avoid with bevacizumab, fluorouracil, irinotecan and oxaliplatin.
Folinic acid: avoid concomitant use.
Live vaccines: avoid concomitant use.

Metabolism

Saturable elimination mediated via reticuloendothelial system, and internalisation and degradation of EGFR.

PanitumumabSupplier

Wuhan Chemstan Biotechnology Co., Ltd. Gold
Tel
15926423062
Email
422450190@qq.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Wuhan Sunrise Technology Development Co., Ltd.
Tel
027-027-83314682 13554138826
Email
whsrtech@vip.163.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com