2-PIPERIDIN-1-YL-BENZALDEHYDE Chemical Properties

Melting point:

95 °C(Solv: ethanol (64-17-5))

Boiling point:

143 °C(Press: 1.0 Torr)

Density 

1.091±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

liquid

pka

4.36±0.40(Predicted)

color 

Clear, yellow / oil

CAS DataBase Reference

34595-26-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-52

Safety Statements 

26

HazardClass 

IRRITANT

HS Code 

2913000090

2-PIPERIDIN-1-YL-BENZALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-piperidinyl-1-benzaldehyde from hexahydropyridine and 2-fluorobenzaldehyde: To a solution of 2-fluorobenzaldehyde (20 g, 161.1 mmol) in anhydrous DMF (160 ml) was added piperidine (19.1 ml, 193.4 mmol, 1.2 eq.) and potassium carbonate (26.73 g, 193.4 mmol, 1.2 eq.), in that order. . The suspension was heated with stirring at 130 °C for 3 hours. After completion of the reaction, the reaction mixture was poured into cold water. The pH was adjusted with citric acid to 5. The aqueous layer was extracted three times with ethyl acetate (EtOAc), the organic phases were combined and washed sequentially with water, saturated sodium bicarbonate (NaHCO3) solution and brine. The organic phase was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give the target product 2-piperidinyl-1-benzaldehyde as a red oil (28.23 g, 92% yield).

References

[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 8, p. 1950 - 1953
[2] Heterocycles, 2008, vol. 75, # 4, p. 799 - 838
[3] Patent: WO2004/108673, 2004, A2. Location in patent: Page 38-39
[4] Patent: US2004/192921, 2004, A1. Location in patent: Page 4
[5] Russian Chemical Bulletin, 2004, vol. 53, # 6, p. 1240 - 1247

2-PIPERIDIN-1-YL-BENZALDEHYDE(34595-26-1)Related Product Information

• 2-PIPERIDIN-1-YL-BENZALDEHYDE
• 4-PIPERIDIN-1-YL-BENZALDEHYDE, 95+%,4-PIPERIDIN-1-YL-BENZALDEHYDE
• 5-AMINO-2-PIPERIDIN-1-YL-BENZAMIDE
• 5-NITRO-2-PIPERIDINOBENZALDEHYDE
• 2-[4-(ETHOXYCARBONYL)PIPERIDINO]-5-NITROBENZENECARBOXYLIC ACID
• 2-PIPERIDINOBENZAMIDE
• ETHYL 1-[4-AMINO-2-(METHOXYCARBONYL)PHENYL]-4-PIPERIDINECARBOXYLATE
• 3-NITRO-2,6-DIPIPERIDINOBENZOIC ACID
• 1-(2-FORMYLPHENYL)PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
• 2-PIPERIDINOBENZOIC ACID
• 5-AMINO-2-PIPERIDIN-1-YL-BENZOIC ACID
• 2-(4-METHYLPIPERIDIN-1-YL)-5-NITROBENZOIC ACID
• 5-AMINO-2-(4-METHYL-PIPERIDIN-1-YL)-BENZAMIDE
• 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID
• 5-NITRO-2-(3-METHYLPIPERIDIN-1-YL)BENZOIC ACID
• 4-(3-METHYL-PIPERIDIN-1-YL)-BENZALDEHYDE
• 2-METHOXY-4-PIPERIDIN-1-YL-BENZALDEHYDE
• 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde