3-AMINO-5-CHLORO-BENZONITRILE Chemical Properties

Boiling point:

309.0±22.0 °C(Predicted)

Density 

1.33

storage temp. 

2-8°C, protect from light

pka

1.73±0.10(Predicted)

form 

Powder

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

Hazard Note 

Irritant

HS Code 

2926907090

3-AMINO-5-CHLORO-BENZONITRILE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-amino-5-chlorobenzonitrile from 3-chloro-5-nitrobenzonitrile was as follows: 3-chloro-5-nitrobenzonitrile was dissolved in DMF at room temperature, and 6 equivalents of SnCl2-2H2O was added, and the reaction was carried out overnight for reduction. After completion of the reaction, the target product was purified by silica gel column chromatography in 40% yield. LCMS analysis of the product (Condition A) showed a retention time of 1.61 min and a molecular ion peak [M+H]+ of 153.1.1 The 1H NMR (500 MHz, CDCl3) data were as follows: δ 6.97 (s, 1H), 6.84 (t, J = 2.0 Hz, 1H), 6.77 (s, 1H).

References

[1] Patent: US2006/287287, 2006, A1. Location in patent: Page/Page column 17-18

3-AMINO-5-CHLORO-BENZONITRILE(53312-78-0)Related Product Information

• 3-AMINO-4-BROMOPHENOL
• 3-Aminophenol hemisulfate
• 5-Bromopicolinic acid
• Terpinyl acetate
• Oseltamivir phosphate
• 2,5-Dibromo-3-nitropyridine
• 2-PYRIDYLTHIOUREA
• 2-tert-Butyl-1,4-benzoquinone
• 5-Fluorotryptamine hydrochloride
• 3-AMINO-5-CHLORO-BENZONITRILE
• 2-Amino-3-chloro-5-nitrobenzonitrile
• 2-Amino-5-chlorobenzonitrile
• 2-Amino-4-chlorobenzonitrile
• 2-Amino-6-chlorobenzonitrile
• 3-CHLORO-5-NITROBENZONITRILE
• 2,5-DIAMINO-3-CHLOROBENZONITRILE