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HYDROQUINIDINE

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HYDROQUINIDINE Basic information

Product Name:
HYDROQUINIDINE
Synonyms:
  • (1S)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-Methoxyquinolin-4-yl)Methanol
  • aluminum triacetate
  • Dihydroquinidine,99%d.e.
  • (S)-((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
  • Quinine Sulphate Impurity 1
  • (9s)-10,11-dihydro-6’-methoxycinchonan-9-ol
  • (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
  • 10,11-Dihydroquinidine
CAS:
1435-55-8
MF:
C20H26N2O2
MW:
326.43
EINECS:
215-862-5
Product Categories:
  • Inhibitors
Mol File:
1435-55-8.mol
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HYDROQUINIDINE Chemical Properties

Melting point:
169-170 °C(lit.)
alpha 
226 º (C=2 IN ETOH)
Boiling point:
464.47°C (rough estimate)
Density 
1.1117 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
chloroform: 0.1 g/mL, clear
form 
A crystalline solid
pka
12.80±0.20(Predicted)
color 
White to off-white
optical activity
[α]25/D +226°, c = 2 in ethanol
Merck 
13,4831
BRN 
91441
InChIKey
LJOQGZACKSYWCH-LHFMAAMQSA-N
CAS DataBase Reference
1435-55-8(CAS DataBase Reference)
NIST Chemistry Reference
Hydroquinidine(1435-55-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37-36
RIDADR 
1544
WGK Germany 
3
RTECS 
MX3016000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29339900

MSDS

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HYDROQUINIDINE Usage And Synthesis

Chemical Properties

Solid

Uses

antiarrhythmic, antimalarial

Purification Methods

It is slightly soluble in Et2O and H2O but readily soluble in hot EtOH. [Heidelberger & Jacobs J Am Chem Soc 41 826 1919, King J Chem Soc 523 1946.] The hydrochloride has m 273-274o, [] 26D +184o (c 1.3, MeOH) and is very soluble in MeOH and CHCl3, but less soluble in H2O, EtOH and still less soluble in dry Me2CO. [Kyker & Lewis J Biol Chem 157 707 1945, Emde Helv Chim Acta 15 557 1932, Beilstein 23/13 V 340.]

HYDROQUINIDINE Preparation Products And Raw materials

Preparation Products

HYDROQUINIDINESupplier

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