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Semax

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Semax Basic information

Product Name:
Semax
Synonyms:
  • ACTH (4-7), Pro-Gly-Pro-
  • ACTH (4-7), Pro-Gly-Pro trifluoroacetate salt
  • L-Methionyl-L-a-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline trifluoroacetate salt
  • Met-Glu-His-Phe-Pro-Gly-Pro
  • Semax
  • (PRO8,GLY9,PRO10)ACTH-(4-10)
  • SemaxAcetate
  • L-METHIONYL-L-Α-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-PROLYLGLYCYL-L-PROLINE
CAS:
80714-61-0
MF:
C37H51N9O10S
MW:
813.92
EINECS:
253-368-1
Product Categories:
  • 80714-61-0
Mol File:
80714-61-0.mol
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Semax Chemical Properties

Boiling point:
1335.2±65.0 °C(Predicted)
Density 
1.391±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: >2mg/mL
pka
3.43±0.20(Predicted)
form 
powder
color 
white to tan
Water Solubility 
Soluble to 2 mg/ml in water
Sequence
H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
InChI
InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/s3
InChIKey
AFEHBIGDWIGTEH-YNWVLKOQNA-N
SMILES
N1(CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)CC1N=CNC=1)CC1=CC=CC=C1 |&1:4,15,21,25,29,38,r|
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Safety Information

WGK Germany 
3
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Semax Usage And Synthesis

Description

Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for the production of cortisol which in turn regulates glucose and lipid metabolism and helps to maintain blood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophic factor (BDNF), a protein important in encouraging growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory, coordination, concentration, and learning. Semax also works to activate the dopaminergic and serotonergic systems to help prime the brain for action and to induce a controlled state of mental stress.

benefits

Over continued use, guests have seen benefits such as:Reduces anxiety and depression;Improves mental clarity, memory, and focus

Biological Functions

Semax altered the expression of genes that modulate the amount and mobility of immune cells. It also could enhanced the expression of genes that encode chemokines and immunoglobulins. It can increase attention and short-term memory, improve Non-proliferative Diabetic Neuropathy, and can help during recovery from Stroke/Hypoxia

Mechanism of action

Though the exact mechanism of action of Semax is unclear, there is evidence that it may act through melanocortin receptors. Semax is a neuroprotective peptide, which aims to slow disease progression and secondary injuries by halting/slowing the loss of neurons and is neurorestorative.

Uses

Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.

Clinical Use

Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011. Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.

Side effects

While Semax is widely recognized for its cognitive benefits, like many nootropics, it also has potential side effects. Some individuals have reported instances of headaches, weariness, irritability, and mild stomach pain. It is noteworthy to acknowledge that these adverse effects are infrequent and typically resolve expeditiously. However, anyone considering Semax should consult with a healthcare provider before starting a regimen to gauge personal risk and ensure safe use.

storage

Store at -20°C

SemaxSupplier

Cellmano Biotech Limited Gold
Tel
0551-65326643 18156095617
Email
info@cellmano.com
Sichuan Taihui Biotechnology Co., Ltd Gold
Tel
028-87189093 18599944286
Email
272503470@qq.com
Chengdu Youngshe Chemical Co., Ltd. Gold
Tel
+86-17380623303 +86-17380623303
Email
Caroline@youngshechem.com
Phygene Gold
Tel
18059081430
Email
2070812664@qq.com
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd Gold
Tel
18014456767 18014456767
Email
wenxi@jszkhy.com