Semax Chemical Properties

Boiling point:

1335.2±65.0 °C(Predicted)

Density 

1.391±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

H2O: >2mg/mL

pka

3.43±0.20(Predicted)

form 

powder

color 

white to tan

Water Solubility 

Soluble to 2 mg/ml in water

Sequence

H-Met-Glu-His-Phe-Pro-Gly-Pro-OH

InChI

InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/s3

InChIKey

AFEHBIGDWIGTEH-YNWVLKOQNA-N

SMILES

N1(CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)CC1N=CNC=1)CC1=CC=CC=C1 |&1:4,15,21,25,29,38,r|

Safety Information

WGK Germany 

3

Semax Usage And Synthesis

Description

Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for the production of cortisol which in turn regulates glucose and lipid metabolism and helps to maintain blood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophic factor (BDNF), a protein important in encouraging growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory, coordination, concentration, and learning. Semax also works to activate the dopaminergic and serotonergic systems to help prime the brain for action and to induce a controlled state of mental stress.

benefits

Over continued use, guests have seen benefits such as:Reduces anxiety and depression;Improves mental clarity, memory, and focus

Biological Functions

Semax altered the expression of genes that modulate the amount and mobility of immune cells. It also could enhanced the expression of genes that encode chemokines and immunoglobulins. It can increase attention and short-term memory, improve Non-proliferative Diabetic Neuropathy, and can help during recovery from Stroke/Hypoxia

Mechanism of action

Though the exact mechanism of action of Semax is unclear, there is evidence that it may act through melanocortin receptors. Semax is a neuroprotective peptide, which aims to slow disease progression and secondary injuries by halting/slowing the loss of neurons and is neurorestorative.

Uses

Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.

Clinical Use

Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011. Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.

storage

Store at -20°C

Semax(80714-61-0)Related Product Information

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