3-Hydroxypivalic acid Chemical Properties

Melting point:

−16 °C(lit.)

Boiling point:

164-166 °C20 mm Hg(lit.)

Density 

1.221 g/mL at 25 °C(lit.)

vapor pressure 

0.446Pa at 25℃

refractive index 

n20/D 1.5215(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly, Heated), Methanol (Slightly)

form 

powder to crystal

pka

4.55±0.10(Predicted)

color 

White to Almost white

Water Solubility 

Soluble in water.

BRN 

1747025

LogP

-0.02

CAS DataBase Reference

4835-90-9(CAS DataBase Reference)

NIST Chemistry Reference

Hydroxy pivalic acid(4835-90-9)

EPA Substance Registry System

Hydroxypivalic acid (4835-90-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-41-37/38

Safety Statements 

26-37/39

WGK Germany 

1

RTECS 

KM2975000

F 

3-13-23

TSCA 

Yes

HS Code 

2918.19.9000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Hydroxypivalic acid Usage And Synthesis

Chemical Properties

white crystal

Uses

3-Hydroxy-2,2-dimethylpropionic acid is used as pharmaceutical intermediate.

Reactions

When 3-Hydroxypivalic acid (1r) was used under standard conditions, the free hydroxyl group was well tolerated and after conjugated addition, the lactonization took place smoothly to afford compound 3ra as a single diastereoisomer (according to 1H- and 13C-NMR)^[1].
Tandem decarboxylation-Giese reaction-lactonization

Flammability and Explosibility

Not classified

References

[1] NIEVES P. RAMIREZ; Jose C G G. Decarboxylative Giese-Type Reaction of Carboxylic Acids Promoted by Visible Light: A Sustainable and Photoredox-Neutral Protocol[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201601478.

3-Hydroxypivalic acid(4835-90-9)Related Product Information

• Citric acid
• Hyaluronic acid
• ETHANE
• Dimethyl carbonate
• 10-Hydroxycamptothecin
• 2,3-Dibromopropionic acid
• Methylparaben
• N,N-Dimethylformamide
• 3-(4-Hydroxyphenyl)propionic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Hydroxy silicone oil
• Dimethyl sebacate
• Dimethyl sulfoxide
• Chloromethyl pivalate
• 4-Hydroxybenzoic acid
• Dimethyl fumarate
• L(+)-Lactic acid
• 4-Hydroxybenzaldehyde