4-FLUOROBENZENESULFINIC ACID SODIUM SALT Chemical Properties

Melting point:

>250°C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

824-80-6(CAS DataBase Reference)

Safety Information

HS Code 

2930909899

4-FLUOROBENZENESULFINIC ACID SODIUM SALT Usage And Synthesis

Chemical Properties

white powder

Synthesis

GENERAL STEPS: In a 250 mL single-necked round-bottomed flask, 4-fluorobenzenesulfonyl chloride (48.5 mmol, 9.4 g, 1.0 eq.), sodium sulfite (97 mmol, 12.2 g, 2.0 eq.), and sodium bicarbonate (97 mmol, 8.1 g, 2.0 eq.) were added in sequence, followed by 60 mL of water. A reflux condenser was installed and the reaction was stirred in an oil bath at 80 °C for 4 hours. Upon completion of the reaction, the water was removed by distillation under reduced pressure and the residue was dissolved in methanol and filtered. The filtrate was concentrated by rotary evaporator to remove methanol, and 10.2 g of sodium p-fluorobenzenesulfinate was obtained as a white solid product with 99% yield.

References

[1] Patent: CN107033046, 2017, A. Location in patent: Paragraph 0192; 0193; 0194
[2] Chemistry - An Asian Journal, 2016, vol. 11, # 15, p. 2121 - 2125
[3] Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry, 1976, vol. A30, # 8, p. 579 - 585
[4] European Journal of Medicinal Chemistry, 2007, vol. 42, # 6, p. 880 - 884
[5] Journal of Organic Chemistry, 1992, vol. 57, # 9, p. 2594 - 2599

4-FLUOROBENZENESULFINIC ACID SODIUM SALT(824-80-6)Related Product Information

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