corydalmine Chemical Properties

Melting point:

177-178℃

Boiling point:

501.2±50.0 °C(Predicted)

Density 

1.29

storage temp. 

Store at -20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

9.97±0.20(Predicted)

corydalmine Usage And Synthesis

Uses

Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

in vivo

target

P450 (e.g. CYP17) | Antifection

IC 50

CXCR2

References

[1] S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. DOI:10.4489/MYCO.2007.35.2.069
[2] Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. DOI:10.1016/j.jpba.2016.05.024
[3] Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. DOI:10.1016/j.neuropharm.2018.03.004

corydalmine(30413-84-4)Related Product Information

• DEHYDROCAVIDINE
• CORYSAMINE CHLORIDE(RG)
• Tetrahydroberberine
• L-Hyoscyamine
• Protopine
• Xanthiazone
• Daurinoline
• daurisoline
• Tetrahydropalmatine
• 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one
• Xanthiside
• VERATRINE
• menisdaurin
• Corydaline
• VERATRIDINE
• Hydroprotopine
• Dehydrocorydaline
• (+)-Corlumidine