Basic information Synthesis Safety Supplier Related

1-Benzyl-3-ethoxycarbonyl-4-piperidone

Basic information Synthesis Safety Supplier Related

1-Benzyl-3-ethoxycarbonyl-4-piperidone Basic information

Product Name:
1-Benzyl-3-ethoxycarbonyl-4-piperidone
Synonyms:
  • 1-Benzyl-3-carbethoxy-4-piperidone
  • ethyl 1-benzyl-4-oxopiperidine-3-carboxylate
  • Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate(HCl ForM)
  • 1-(benzyl)-4-keto-nipecotic acid ethyl ester
  • 4-oxo-1-(phenylmethyl)-3-piperidinecarboxylic acid ethyl ester
  • ethyl 4-oxo-1-(phenylmethyl)piperidine-3-carboxylate
  • N-BENZYL-3-CARBOETHOXY-4-PIPERIDONE
  • LABOTEST-BB LT00440756
CAS:
41276-30-6
MF:
C15H19NO3
MW:
261.32
Product Categories:
  • pharmacetical
Mol File:
41276-30-6.mol
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1-Benzyl-3-ethoxycarbonyl-4-piperidone Chemical Properties

Boiling point:
379.7±42.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
10.77±0.20(Predicted)
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1-Benzyl-3-ethoxycarbonyl-4-piperidone Usage And Synthesis

Synthesis

To a suspension of NaH (5.38 g, 0.13 mol) in benzene, a solution of Michael adduct 131 (25 g, 0.09 mol) in PhH was added drop-wise and refluxed for 3 hours. The reaction mixture was allowed to cool and quenched with saturated NH4Cl solution, extracted with ethyl acetate, washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. Column chromatographic separation over silica gel (EtOAc- pet ether) afforded ketoester, as a pale yellow oil (18.15 g).

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