alpha,beta-dihydroxyisovaleric acid Chemical Properties

Melting point:

94 °C

Boiling point:

332.2±27.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly)

pka

3+-.0.27(Predicted)

form 

Solid

color 

Off-White to Pale Beige

Stability:

Moisture Sensitive

alpha,beta-dihydroxyisovaleric acid Usage And Synthesis

Uses

2,3-Dihydroxyisovaleric acid (2,3-Dihydroxy-3-methylbutanoic acid) is a natural metabolite of the branched-chain amino acid leucine that has been found present in the urine of a patient with 2-hydroxyglutaric aciduria[1].

Definition

ChEBI: A dihydroxy monocarboxylic acid that is isovaleric acid which is substituted by hydroxy groups at positions 2 and 3.

References

[1] F B Armstrong, et al. Stereoselectivity and stereospecificity of the alpha,beta-dihydroxyacid dehydratase from Salmonella typhimurium. Biochim Biophys Acta. 1977 Jul 21;498(1):282-93. DOI:10.1016/0304-4165(77)90266-5