asterric acid Chemical Properties

Melting point:

208-214 °C

Boiling point:

557.6±50.0 °C(Predicted)

Density 

1.406±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide

form 

solid

pka

2.97±0.34(Predicted)

color 

white

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

asterric acid Usage And Synthesis

Uses

Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.

Biological Activity

asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.

in vitro

previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].

IC 50

10 μm for et-1 binding to the eta receptor ofa10 cells

References

[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).

asterric acid(577-64-0)Related Product Information

• METHYL 2-PHENOXYBENZOATE
• 2,6-Dihydroxybenzoic acid
• BIS(2-FORMYLPHENYL) ETHER
• 2,5-Dihydroxybenzoic acid
• 3-Methoxysalicylic acid
• Methyl 3-methoxysalicylate
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• 2,3-Dimethoxybenzoic acid
• 2,3-Dihydroxybenzoic acid
• methyl 2,3-dihydroxybenzoate
• methyl 5-hydroxy-2-methoxybenzoate
• 2-PHENOXYBENZOIC ACID
• Methyl 2,5-dihydroxybenzoate
• 4-Methylsalicylic acid
• asterric acid
• 2,6-DIHYDROXY-4-METHYLBENZALDEHYDE
• 3-HYDROXY-6-METHOXYBENZOIC ACID
• 2,6-DIHYDROXY-4-METHYLBENZOIC ACID