4-Deoxypyridoxine hydrochloride Chemical Properties

Melting point:

274°C(dec.)(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated)

form 

Solid

color 

White to Pale Red

Stability:

Hygroscopic

CAS DataBase Reference

148-51-6(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

UT4800000

HS Code 

29333990

Toxicity

LD50 oral in chicken: 1570mg/kg

MSDS

• Language:English Provider:SigmaAldrich

4-Deoxypyridoxine hydrochloride Usage And Synthesis

Description

4-deoxy Pyridoxine (DOP) is a vitamin B₆ antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells. DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos. It decreases latency to first seizure in mice (ED₅₀ = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. DOP reduces TNF-α and IL-6 production in mice infected with T. spiralis.

Chemical Properties

Solid

Uses

4-Deoxypyridoxine is the deoxy analogue of Pyridoxine (P991735). 4-Deoxypyridoxine is a vitamin B6 antimetabolite; 4-Deoxypyridoxine can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.

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