deltonin
deltonin Basic information
- Product Name:
- deltonin
- Synonyms:
-
- deltonin
- 3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin
- Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin
- β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
- Deltonin,Akt,Protein kinase B,PKB,Inhibitor,Extracellular signal regulated kinases,inhibit,ERK,Endogenous Metabolite
- Deltonin, 10 mM in DMSO
- CAS:
- 55659-75-1
- MF:
- C45H72O17
- MW:
- 885.04
- Mol File:
- 55659-75-1.mol
deltonin Chemical Properties
- Melting point:
- 298-300 °C (decomp)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- pka
- 12?+-.0.70(Predicted)
- form
- Solid
- color
- White to off-white
deltonin Usage And Synthesis
Uses
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.
Definition
ChEBI: Deltonin is a triterpenoid.
in vivo
Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice[1].
IC 50
ERK1; ERK2; Akt
References
[1] Tong QY, et al. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42. DOI:10.1159/000327949
[2] Zhang S, et al. Deltonin induces apoptosis in MDA?MB?231 human breast cancer cells via reactive oxygen species?mediated mitochondrial dysfunction and ERK/AKT signaling pathways. Mol Med Rep. 2013 Mar;7(3):1038-44. DOI:10.3892/mmr.2013.1273
deltoninSupplier
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
- Tel
- 021-61317773
- sales@aspirebio.com
deltonin(55659-75-1)Related Product Information
- Bufalin
- Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)-
- beta-Sitosterol
- 22,25-Epoxy-2,3,14,20-tetrahydroxycholest-7-en-6-one
- ALLEOSIDE A
- Resibufogenin
- Bufotaline
- Hydroxyecdysone
- (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside
- poricoic acid A 3-methyl ester
- Notoginsenoside R2
- ginsenoside F4
- dehydrotumulosic acid
- panaxydol
- Dipsanoside A
- Dipsanoside B