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2-Hydroxypyridine

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2-Hydroxypyridine Basic information

Product Name:
2-Hydroxypyridine
Synonyms:
  • 1-Hydroxy-2-pyridine
  • 2(1h)-pyridinone
  • alpha-Pyridone
  • Pyridone-2
  • AURORA KA-3075
  • A-PYRIDONE
  • TIMTEC-BB SBB004392
  • a-Hydroxypyridine
CAS:
142-08-5
MF:
C5H5NO
MW:
95.1
EINECS:
205-520-3
Product Categories:
  • Others
  • Pyridines
  • Pyridine
  • Pyridines derivates
  • Building Blocks
  • C5
  • (intermediate of benzoxazole)
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Nucleotides
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • bc0001
Mol File:
142-08-5.mol
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2-Hydroxypyridine Chemical Properties

Melting point:
105-107 °C (lit.)
Boiling point:
280-281 °C (lit.)
Density 
1.39
refractive index 
1.5939 (estimate)
Flash point:
210 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
450g/l
pka
0.75(at 20℃)
form 
Liquid
color 
Colorless to yellow to brown, darken on storage with no loss of purity
Water Solubility 
Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.
BRN 
105786
CAS DataBase Reference
142-08-5(CAS DataBase Reference)
NIST Chemistry Reference
2(1H)-Pyridinone(142-08-5)
EPA Substance Registry System
2(1H)-Pyridinone (142-08-5)
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Safety Information

Hazard Codes 
Xi,Xn,T
Risk Statements 
36/37/38-40-25
Safety Statements 
26-36-37/39-22-45-36/37/39
RIDADR 
UN2811
WGK Germany 
3
RTECS 
UV1144050
8
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
Toxicity
LD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85

MSDS

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2-Hydroxypyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal

Uses

Catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.

Uses

2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.

Definition

ChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite.

General Description

2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs).

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]

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