2-Hydroxypyridine Chemical Properties

Melting point:

105-107 °C (lit.)

Boiling point:

280-281 °C (lit.)

Density 

1.39

refractive index 

1.5939 (estimate)

Flash point:

210 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

450g/l

pka

0.75(at 20℃)

form 

Liquid

color 

Colorless to yellow to brown, darken on storage with no loss of purity

Water Solubility 

Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.

BRN 

105786

LogP

-0.593 (est)

CAS DataBase Reference

142-08-5(CAS DataBase Reference)

NIST Chemistry Reference

2(1H)-Pyridinone(142-08-5)

EPA Substance Registry System

2(1H)-Pyridinone (142-08-5)

Safety Information

Hazard Codes 

Xi,Xn,T

Risk Statements 

36/37/38-40-25

Safety Statements 

26-36-37/39-22-45-36/37/39

RIDADR 

UN2811

WGK Germany 

3

RTECS 

UV1144050

F 

8

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

Toxicity

LD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85

MSDS

• Language:English Provider:2-Hydroxypyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Hydroxypyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal

Uses

2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.

Uses

Catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.

Definition

ChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite.

General Description

2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs).

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]

2-Hydroxypyridine(142-08-5)Related Product Information

• Hydroxy silicone oil
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• (+/-)-NICOTINE
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• 2-(Hydroxymethyl)pyridine
• 2-Chloro-5-chloromethylpyridine
• Sulfasalazine
• 2,5-Dimethylpyridine
• Chromium picolinate
• 4-Hydroxypyridine
• Pyridin-2-ol
• Levetiracetam impurity 8
• Levetiracetam acid
• LevetiracetaM IMpurity B
• (S)-N-(1-aMino-1-oxobutan-2-yl)-4-chlorobutanaMide
• alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid
• Levetiracetam impurity 6
• Levetiracetam