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cleomiscosin A

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cleomiscosin A Basic information

Product Name:
cleomiscosin A
Synonyms:
  • (2R,3R)-rel-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-9H-pyrano[2,3-f]-1,4-benzodioxin-9-one
  • NSC 346197
  • cleomiscosin A
  • 9H-Pyrano[2,3-f]-1,4-benzodioxin-9-one,2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-,(2R,3R)-rel-
  • (2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one
CAS:
76948-72-6
MF:
C20H18O8
MW:
386.35
Mol File:
76948-72-6.mol
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cleomiscosin A Chemical Properties

Melting point:
245-247℃
Boiling point:
632.7±55.0 °C(Predicted)
Density 
1.403
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Acetonitrile (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)
pka
9.65±0.35(Predicted)
form 
Solid
color 
White to Off-White
LogP
2.161 (est)
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cleomiscosin A Usage And Synthesis

Uses

Cleomiscosin A is a known coumarinolignan and an important constituent of the methanolic extract of Hyoscyamus niger seeds (MHN) responsible for anti-inflammatory activity.

Definition

ChEBI: An organic heterotricyclic compound that is 2,3-dihydro-9H-[1,4]dioxino[2,3-h]chromen-9-one substituted by 4-hydroxy-3-methoxy phenyl group at position 3, a hydroxymethyl group at position 2 and a methoxy group at position 5 (the 2R,3R stereoisomer). It exhibits anti-inflammatory activity.

target

LDL | TNF-α

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