3,5-Dichloro-2-pyridinecarboxylic acid Chemical Properties

Melting point:

153-154 °C

Boiling point:

315.4±37.0 °C(Predicted)

Density 

1.612±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder

pka

2.12±0.25(Predicted)

color 

White

CAS DataBase Reference

81719-53-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

2933399990

3,5-Dichloro-2-pyridinecarboxylic acid Usage And Synthesis

Synthesis

General procedure for the synthesis of 3,5-dichloro-2-pyridinecarboxylic acid from 2-cyano-3,5-dichloropyridine: 3,5-dichloro-2-pyridinecarbonitrile (10 g, 57.8 mmol) was dissolved in 100 mL of 95% concentrated sulfuric acid, and the reaction mixture was heated to 115 °C and kept reacting overnight. Upon completion of the reaction, the mixture was cooled to room temperature, followed by slow pouring into ice water and vigorous stirring. The precipitated solid product was collected by filtration, washed thoroughly with cold water and finally dried under reduced pressure at 40 °C to give 9.4 g of white solid product in 85% yield.

References

[1] Patent: WO2009/89263, 2009, A2. Location in patent: Page/Page column 117

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