neritaloside
neritaloside Basic information
- Product Name:
- neritaloside
- Synonyms:
-
- neritaloside
- Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
- CAS:
- 465-13-4
- MF:
- C32H48O10
- MW:
- 592.73
- Mol File:
- 465-13-4.mol
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neritaloside Chemical Properties
- Melting point:
- 135-140 °C
- Boiling point:
- 729.4±60.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- pka
- 12.92±0.70(Predicted)
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neritaloside Usage And Synthesis
Uses
Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.
in vivo
Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2.
| Animal Model: | Mice of NMRI strain (18-22 g) [2 |
| Dosage: | 25 mg/kg |
| Administration: | Intraperitoneal injection; for 6 hours |
| Result: | Showed sedation in mice at 25 mg/kg dose. |
References
[1] Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8. DOI:10.1016/j.jep.2011.01.038
[2] Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8. DOI:10.1016/s0031-9422(98)00523-8
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