polymyxin B(1)
polymyxin B(1) Basic information
- Product Name:
- polymyxin B(1)
- Synonyms:
-
- (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
- polymyxin B(1)
- (-)-N2-[[(6S)-6-Methyloctanoyl]-L-A2bu-L-Thr-L-A2bu-]cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
- polymyxin B1Q: What is polymyxin B1 Q: What is the CAS Number of polymyxin B1
- (S)-N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide
- Polymyxin B1-[13C6,15N] TFA salt
- Glucosamine Hydrochloride Impurity 33
- CAS:
- 4135-11-9
- MF:
- C56H98N16O13
- MW:
- 1203.48
- Mol File:
- 4135-11-9.mol
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polymyxin B(1) Chemical Properties
- Boiling point:
- 838.79°C (rough estimate)
- Density
- 1.0500 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Store at -20°C
- solubility
- PBS (pH 7.2): 2 mg/ml
- form
- A crystalline solid
- pka
- 13.08±0.70(Predicted)
- color
- White to off-white
- Sequence
- {Dab(6-methyl-1-oxooctyl)}-Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam bridge: Dab4-Thr10)
- InChIKey
- WQVJHHACXVLGBL-CTMZAJDNSA-N
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polymyxin B(1) Usage And Synthesis
Uses
An antibacterial compound. It has a high volume of distribution and longer elimination half-life in patient with multidrug-resistant gram-negative bacterial infection.
Definition
ChEBI: A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus.
in vivo
The pharmacokinetics of Polymyxin B1 is investigated in a rat model following intravenous administration (0.8 mg/kg). The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC0-∞ is 365 mg min/L[5].
polymyxin B(1)Supplier
Heyuan broad spectrum Biotechnology Co., Ltd Gold
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- 0762-3393039 18023108599
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SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD Gold
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- 021-13917490980 13917490980
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J & K SCIENTIFIC LTD.
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- 18210857532; 18210857532
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
Bide Pharmatech Ltd.
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- 400-400-164-7117 18317119277
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