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humantenirine

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humantenirine Basic information

Product Name:
humantenirine
Synonyms:
  • humantenirine
  • 4-Demethyl-11-methoxyhumantenine
  • Spiro[3H-indole-3,8'(7'H)-[4,7]methanooxepino[4,3-b]pyridin]-2(1H)-one, 3'-ethylidene-1',2',3',4',4'a,5',9',9'a-octahydro-1,6-dimethoxy-, (3S,3'Z,4'R,4'aS,7'R,9'aS)-
  • Humanlenirine
CAS:
82375-30-2
MF:
C21H26N2O4
MW:
370.44
Mol File:
82375-30-2.mol
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humantenirine Chemical Properties

solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
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humantenirine Usage And Synthesis

Description

Humantenirine is an oxindole alkaloid that has been shown to have potent inhibition of the enzyme activities. It is a natural product that has been isolated from the plant Humantenia nitens, which is found in Gabon, Africa. Humantenirine has a skeleton similar to other indole alkaloids and contains a hydroxy group on one of the rings. This compound has been shown to be stereoselective and monoterpenoid and may have potential as an anti-inflammatory drug.

Chemical Properties

Humantenirine ( C21H26N2O4 colorless cubic crystals, mp 168- 169°C, M+ 370.1944). Its UV spectrum is similar to that of gelsemicine; hence both have the same chromophore, 7-methoxy-3,3-disubstituted N-methoxy-oxindole.

Occurrence

Humantenirine is a natural product found in Gelsemium sempervirens, Gelsemium elegans, and Gelsemium rankinii with data available.

target

P450 (e.g. CYP17)

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