arborinine Chemical Properties

Melting point:

177-177.5 °C

Boiling point:

508.4±50.0 °C(Predicted)

Density 

1.296±0.06 g/cm3(Predicted)

pka

7.29±0.20(Predicted)

arborinine Usage And Synthesis

Uses

Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].

Definition

ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone.

in vivo

IC 50

LSD1

References

[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y

arborinine(5489-57-6)Related Product Information

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