Basic information Safety Supplier Related

escin IIa

Basic information Safety Supplier Related

escin IIa Basic information

Product Name:
escin IIa
Synonyms:
  • escin IIa
  • 82XHO27XQ8
  • AESCIN IIA
  • b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-
  • β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
  • EscinIC
CAS:
158732-55-9
MF:
C54H84O23
MW:
1101.24
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
158732-55-9.mol
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escin IIa Chemical Properties

Boiling point:
1111.9±65.0 °C(Predicted)
Density 
1.45±0.1 g/cm3 (20 ºC 760 Torr)
pka
2.63±0.70(Predicted)
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escin IIa Usage And Synthesis

Uses

Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

in vivo

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2].

Animal Model:Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1]
Dosage:10-50 mg/kg
Administration:p.o.
Result:Showed a potent protective effect against ethanol-induced gastric lesions in rats.

References

[1] Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. DOI:10.1248/bpb.20.1092
[2] Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. DOI:10.1016/s0014-2999(99)00249-6

escin IIaSupplier

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