4-chlorokynurenine Chemical Properties

Melting point:

>165°C (dec.)

Boiling point:

516.3±50.0 °C(Predicted)

Density 

1.454±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Aqueous Acid (Slightly), DMSO (Sparingly)

form 

Solid

pka

2.13±0.23(Predicted)

color 

Pale Yellow to Yellow

4-chlorokynurenine Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. ?Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.

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