MOSLOFLAVONE Chemical Properties

Melting point:

163-164℃ (chloroform , acetone )

Boiling point:

508.5±50.0 °C(Predicted)

Density 

1.321±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

pka

6.32±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

biological source

plant

Water Solubility 

water: slightly soluble

InChI

InChI=1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3

InChIKey

SIVAITYPYQQYAP-UHFFFAOYSA-N

SMILES

C1(C2=CC=CC=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1

MOSLOFLAVONE Usage And Synthesis

Chemical Properties

Yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Scutellaria baicalensis.

Uses

Mosloflavon is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: Mosloflavone is a member of flavonoids and an ether.

Biological Activity

Mosloflavanone exhibits potent anti-EV71 activity by reducing visible cytopathic effects and suppressing virus replication during the initial infection phase. It also hinders the expression of the viral VP2 protein, thereby impeding viral capsid protein synthesis. Additionally, Mosloflavone demonstrates significant anti-inflammatory potential through the inhibition of TNF-α and IL-1β, with IC50 values of 16.4 μM and 6.4 μM, respectively. It shows a dose-dependent reduction in TNF-α, IL-1β, and iNOS levels in the supernatant of the mouse macrophage cell line J774A. This compound holds promise as a foundational element in the quest for treatments targeting inflammatory and immunomodulatory diseases.

MOSLOFLAVONE(740-33-0)Related Product Information

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