7-BROMO-1H-QUINAZOLIN-4-ONE Chemical Properties

Boiling point:

350.1±44.0 °C(Predicted)

Density 

1.82±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

0.36±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

Risk Statements 

36

Safety Statements 

26

HS Code 

2914390090

7-BROMO-1H-QUINAZOLIN-4-ONE Usage And Synthesis

Application

7-Bromo-3,4-dihydroquinazolin-4-one is a quinazolone compound. Quinazolones are a class of nitrogen-containing heterocyclic compounds with good biomedical activity, due to their broad range of biological and pharmaceutical activities.

Synthesis

General procedure for the synthesis of 7-bromo-3,4-dihydroquinazolin-4-one from 2-amino-4-bromobenzoic acid and compound (CAS: 77287-34-4): 0.0 g (1.56 mol) of 2-amino-4-bromobenzoic acid was suspended in 970 mL of formamide, followed by stirring of the reaction for 12 hours at 170°C. Upon completion of the reaction, a conventional post-processing was carried out to give 326.0 g of 7-bromo-3H-quinazolin-4-one; which was analyzed by HPLC/MS as a solid product with (M + H)+ = 226.

References

[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0182
[2] Patent: WO2010/146173, 2010, A1. Location in patent: Page/Page column 16
[3] Patent: CN105503744, 2016, A. Location in patent: Paragraph 0033; 0036; 0037
[4] Journal of Organic Chemistry, 1952, vol. 17, p. 149,153
[5] Patent: US2016/31860, 2016, A1. Location in patent: Paragraph 0110; 0111

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