4,4,4-Trifluoro-3-oxobutanenitrile Chemical Properties

Boiling point:

43 °C(Press: 2.5 Torr)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

2.74±0.10(Predicted)

Safety Information

HS Code 

2926907090

4,4,4-Trifluoro-3-oxobutanenitrile Usage And Synthesis

Uses

4,4,4-Trifluoro-3-oxobutanenitrile (cas# 110234-68-9) is used as a reagent in the preparation of ((dimethoxyquinazolinyloxy)phenyl)urea derivatives as orally efficacious inhibitors of V-RAF murine sarcoma viral oncogene. Additionally, it is used as a reagent in preparation of orally active inhibitors of Brahma homolog (BRM)/SMARCA2 ATPase activity for treatment of Brahma related gene 1 (BRG1)/SMARCA4-mutant cancers. It is also used as a reagent in the synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from fluorinated precursors.

4,4,4-Trifluoro-3-oxobutanenitrile(110234-68-9)Related Product Information

• 3-Oxobutanenitrile
• BUTYRONITRILE
• 2-(4-BROMO-PHENYL)-4,4,4-TRIFLUORO-3-OXO-BUTYRONITRILE
• 4,4,4-TRIFLUORO-2-(3-METHOXY-PHENYL)-3-OXO-BUTYRONITRILE
• 2-(4-CHLOROPHENYL)-4,4,4-TRIFLUORO-3-(OXO)BUTANENITRILE
• 3-(DIMETHYLAMINO)-2-(2,2,2-TRIFLUOROACETYL)ACRYLONITRILE
• (Z)-3-(2-[5-[(4-CHLOROPHENYL)SULFANYL]-4-(2,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINO)-2-(2,2,2-TRIFLUOROACETYL)-2-PROPENENITRILE
• 4,4,4-Trifluoro-3-oxobutanenitrile
• 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE
• 4,4,4-TRIFLUORO-2-(3-FLUORO-PHENYL)-3-OXO-BUTYRONITRILE
• 2-(3-BROMO-PHENYL)-4,4,4-TRIFLUORO-3-OXO-BUTYRONITRILE
• 4,4,4-TRIFLUORO-2-(4-METHOXY-PHENYL)-3-OXO-BUTYRONITRILE
• 4,4,4-TRIFLUORO-2-(4-FLUORO-PHENYL)-3-OXO-BUTYRONITRILE