Dihydrotanshinone I
Dihydrotanshinone I Basic information
- Product Name:
- Dihydrotanshinone I
- Synonyms:
-
- (-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione
- Dihydrotanshinone I 87205-99-0
- 1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione
- 4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione
- Dihydrotanshinone Ⅰ, froM Salvia Miltiorrhiza
- (1R)-1,6-diMethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
- Dihydrotanshinone I
- 15,16-Dihydrotanshine I
- CAS:
- 87205-99-0
- MF:
- C18H14O3
- MW:
- 278.3
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 87205-99-0.mol
Dihydrotanshinone I Chemical Properties
- Melting point:
- 214.0 to 218.0 °C
- Boiling point:
- 479.2±45.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble1mg/mL, clear, orange to red
- form
- powder
- color
- red
- biological source
- Salvia miltiorrhiza
- λmax
- 239nm(lit.)
Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 22-50
- Safety Statements
- 61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- SF8282630
- HS Code
- 29329990
- Hazardous Substances Data
- 87205-99-0(Hazardous Substances Data)
Dihydrotanshinone I Usage And Synthesis
Chemical Properties
Red powder
Uses
Dihydrotanshinone I, an extract from Salvia miltiorrhiza Bunge, is an anti-cancer agent which has been shown to induce apoptosis in human colorectal cancer cells.
Definition
ChEBI: Dihydrotanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent.
Biological Activity
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
in vivo
Dihydrotanshinone I (10 and 25 mg/kg) significantly attenuates atherosclerotic plaque formation, alteres serum lipid profile, decreases oxidative stress and shrinks necrotic core areas in ApoE-/- mice. Dihydrotanshinone I dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta[1].
Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats[2].
Dihydrotanshinone ISupplier
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