5,7,8,4''-TETRAMETHOXYFLAVONE CAS#: 6601-66-7

5,7,8,4''-TETRAMETHOXYFLAVONE Basic information

Product Name:

5,7,8,4''-TETRAMETHOXYFLAVONE

Synonyms:

8-Tetramethoxyflavone
5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)-
5,7,8,4'- tetramethoxyflavone 6-Demethoxytangeretin
tetramethylisoscutellarein
Cluster of differentiation 246,6Demethoxytangeretin,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,6-Demethoxytangeretin,CD246,inhibit,ALK tyrosine kinase receptor,6 Demethoxytangeretin,Inhibitor
5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
4’,5,7,8-Tetramethoxyflavone

CAS:

6601-66-7

MF:

C19H18O6

MW:

342.34

Product Categories:

Tetra-substituted Flavones

Mol File:

6601-66-7.mol

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5,7,8,4''-TETRAMETHOXYFLAVONE Chemical Properties

Melting point:: 216-217℃ (methanol )
Boiling point:: 536.9±50.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white

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5,7,8,4''-TETRAMETHOXYFLAVONE Usage And Synthesis

Chemical Properties

Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Citrus aurantium.

Uses

6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons[1][2].

References

[1] Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. DOI:10.1248/bpb.b13-00875
[2] Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. DOI:10.1007/s00702-013-1025-x

5,7,8,4''-TETRAMETHOXYFLAVONESupplier

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